Dr. Barcellos-Hoff is a Professor and Vice Chair in the Department of Radiology at the University of California San Francisco. Her lab has two broad objectives.  One is to use mouse models to determine critical cell, phenotype and tissue interactions that modulate the mammary carcinogenesis and the spectrum of intrinsic subtypes in breast cancer.  The other is to identify targetable TGFβ biology in tumors and the tumor microenvironment that mediate response to therapy.  Recent publications include identification of TGFβ as a critical regulator in the DNA damage sensitivity in HPV+ cancer and as a cell survival factor in innate immunity.  Dr. Barcellos-Hoff received an undergraduate degree from the University of Chicago and earned a doctoral in experimental pathology from the University of California, San Francisco (UCSF). She conducted postdoctoral research on extracellular matrix and functional differentiation at the Lawrence Berkeley National Laboratory, which she joined as a staff scientist in 1988 and rose to Senior Scientist and Associate Director of the Life Sciences Division.  She joined the faculty of New York University School of Medicine in 2008 and moved to UCSF in 2015.